Registered Cardiovascular Invasive Specialist (RCIS) Practice Test

What is one common side effect associated with ACE inhibitors?

1. Nausea

2. Dry cough

3. Dizziness

4. Fatigue

The correct answer is: Dry cough

One common side effect associated with ACE inhibitors is a dry cough. This phenomenon occurs due to the accumulation of bradykinin, a peptide that is normally broken down by angiotensin-converting enzyme (ACE). When ACE is inhibited by medication, bradykinin levels can increase. Elevated bradykinin may lead to increased sensitivity in the respiratory tract, resulting in a persistent cough in some patients. It's important to note that while nausea, dizziness, and fatigue can occur with various medications, they are not as commonly associated with ACE inhibitors as the dry cough. This unique side effect is noteworthy and can sometimes necessitate a switch to a different class of medication if it becomes bothersome to the patient. Understanding this side effect helps clinicians manage patient expectations and ensure appropriate follow-up care.